The role of somatic mutations in immune mediated inflammatory diseases
نویسندگان
چکیده
Inborn errors of immunity (IEI) are caused by germline genetic variants in an ever expanding number genes. Similarly, increasing acquired associated with conditions characterised immune dysregulation. Many these classified within the IEI classification system as ‘phenocopies inborn immunity’, although neither inborn, nor do they always phenocopy a counterpart. This presentation will explore concept ‘acquired immunity’ (AEI) citing key examples, discussing relevant clinical and diagnostic considerations, exploring emerging technologies used to identify characterise them.
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ژورنال
عنوان ژورنال: Pathology
سال: 2023
ISSN: ['1465-3931', '0031-3025']
DOI: https://doi.org/10.1016/j.pathol.2022.12.099